Cytoskeleton of cortical astrocytes as a target to proline through oxidative stress mechanisms.


Hyperprolinemia is an inherited disorder of proline (Pro) metabolism and patients affected by this disease may present neurological manifestations. However, the mechanisms of neural excitotoxicity elicited by hyperprolinemia are far from being understood. Considering the pivotal role of cytoskeletal remodeling in several neurodegenerative pathologies and… (More)
DOI: 10.1016/j.yexcr.2012.11.002


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