Cytoskeleton-based forecasting of stem cell lineage fates.

@article{Treiser2010CytoskeletonbasedFO,
  title={Cytoskeleton-based forecasting of stem cell lineage fates.},
  author={Matthew D Treiser and Eric H. Yang and Simon Gordonov and Daniel M Cohen and Ioannis P. Androulakis and Joachim Kohn and Christopher S. Chen and Prabhas V. Moghe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 2},
  pages={610-5}
}
Stem cells that adopt distinct lineages cannot be distinguished based on traditional cell shape. This study reports that higher-order variations in cell shape and cytoskeletal organization that occur within hours of stimulation forecast the lineage commitment fates of human mesenchymal stem cells (hMSCs). The unique approach captures numerous early (24 h), quantitative features of actin fluororeporter shapes, intensities, textures, and spatial distributions (collectively termed morphometric… CONTINUE READING

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