Corpus ID: 19621959

Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.

  title={Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.},
  author={S. Tommasi and A. Mangia and R. Lacalamita and A. Bellizzi and Vita Fedele and A. Chiriatti and C. Thomssen and Nancy Kendzierski and A. Latorre and V. Lorusso and F. Schittulli and F. Zito and M. Kavallaris and A. Paradiso},
  journal={International journal of cancer},
  volume={120 10},
  • S. Tommasi, A. Mangia, +11 authors A. Paradiso
  • Published 2007
  • Medicine
  • International journal of cancer
  • The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-binding site of beta-tubulin Class I have been related to paclitaxel resistance in non small cell lung and ovarian cancers. In the present study, we verified the hypothesis of a… CONTINUE READING
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