Corpus ID: 19621959

Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.

@article{Tommasi2007CytoskeletonAP,
  title={Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.},
  author={Stefania Tommasi and Anita Mangia and Rosanna Lacalamita and Antonia Bellizzi and Vita Fedele and Annalisa Chiriatti and Christoph Thomssen and Nancy Kendzierski and Agnese Latorre and Vito Lorusso and Francesco Schittulli and Francesco Alfredo Zito and Maria Kavallaris and Angelo Paradiso},
  journal={International journal of cancer},
  year={2007},
  volume={120 10},
  pages={
          2078-85
        }
}
The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-binding site of beta-tubulin Class I have been related to paclitaxel resistance in non small cell lung and ovarian cancers. In the present study, we verified the hypothesis of a… Expand
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  • L. Pusztai
  • Medicine
  • Annals of oncology : official journal of the European Society for Medical Oncology
  • 2007
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Investigation of the expression and the consequences of βII- and/or βIII-tubulin depletion in interphase microtubule dynamics in non-tumor human mammary epithelial cells finds that both isoforms contribute to the tubulin isotype composition in primary and immortalized human mammaries epithelium cells. Expand
Class III β-tubulin Expression in Colorectal Neoplasms Is a Potential Predictive Biomarker for Paclitaxel Response
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Examination of whether βIII-tubulin (TUBB3), present in various types of normal tissues and cancer, is a biomarker for the response of colorectal neoplasms to paclitaxel found it to be expressed in a subgroup of colurctalNeoplasms. Expand
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