Cytoskeleton and mitochondrial morphology and function

  title={Cytoskeleton and mitochondrial morphology and function},
  author={Lydie Rappaport and Patricia Olivi{\'e}ro and Jane-Lise Samuel},
  journal={Molecular and Cellular Biochemistry},
It has been well established that the cytoskeleton is an essential modulator of cell morphology and motility, intracytoplasmic transport and mitosis, however cytoskeletal linkage to the organelles has not been unequivocally demonstrated. Indeed, cytoskeleton appears to be essential in determining and modulating gene phenotype as a function of cellular environment. According to recent studies, the organization of the cytoskeleton network together with associated protein(s) could be essential in… 
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Studies on the interaction between mitochondria and the cytoskeleton
It is concluded that MAP2 either binds to porin or to a domain of the outer membrane which alters the membrane environment of porin, and the possibility is raised that this domain participates in mitochondrial mobility in situ.
Microtubules in cardiac myocytes.
Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane
Results demonstrate that Mdm10p can control mitochondrial morphology, and that it plays a role in the inheritance of mitochondria.
Behavior of mitochondria in the living cell.
Metabolic compartmentation and substrate channelling in muscle cells
It is proposed that in muscle cells feed-back signal between contraction and mitochondrial respiration may be conducted by metabolic wave (propagation of oscillations of local concentration of ADP and creatine) through cytoplasmic equilibrium creatine and adenylate kinases and is amplified by coupled creatine kinase reaction in mitochondria.
Binding of lipid droplets and mitochondria to intermediate filaments in rat Leydig cells.
The association of droplets and mitochondria with intermediate filaments suggests possible mechanisms by which the transport of cholesterol takes place from droplets to mitochondria where this substrate enters the steroidogenic pathway.
Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria
Emphasis is laid on the methods for visualizing mitochondria in cells and following their behaviour, and Fluorescence methods provide unique possibilities because of their high resolving power and because some of the mitochondria‐specific fluorochromes can be used to reveal the membrane potential.
Association of mitochondria with microtubules in cultured cells.
By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle rat cell line, in monolayer culture, suggesting that mitochondria are directly or indirectly associated with microtubule in these cells.
It is suggested that the axoplasm is morphologically more organized than is sometimes supposed, and that this should be taken into account in attempts to identify the structural basis of neuronal function and especially of the logistic details of the physiological rapport between the cell body and its extensions.