Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells.

@article{Driscoll2015CytoskeletalTN,
  title={Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells.},
  author={Tristan P. Driscoll and Brian D Cosgrove and S. J. Heo and Zach E Shurden and Robert L Mauck},
  journal={Biophysical journal},
  year={2015},
  volume={108 12},
  pages={2783-93}
}
Mechanical forces transduced to cells through the extracellular matrix are critical regulators of tissue development, growth, and homeostasis, and can play important roles in directing stem cell differentiation. In addition to force-sensing mechanisms that reside at the cell surface, there is growing evidence that forces transmitted through the cytoskeleton and to the nuclear envelope are important for mechanosensing, including activation of the Yes-associated protein (YAP)/transcriptional… CONTINUE READING
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