Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress.

Abstract

The cardiovascular disease atherosclerosis is directly linked to the functions of endothelial cells (ECs), which are affected by fluid shear stress (FSS). High, unidirectional FSS causes EC elongation with aligned cytoskeletal components and nonimmunogenic EC functions that protect against atherosclerosis. In contrast, low, oscillatory FSS is associated… (More)
DOI: 10.1152/ajpcell.00340.2009

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