Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation.

@article{Hubchak2003CytoskeletalRA,
  title={Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation.},
  author={Susan C. Hubchak and Constance E. Runyan and Jeffrey I. Kreisberg and H. William Schnaper},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 8},
  pages={1969-80}
}
TGF-beta1 has been implicated in glomerular extracellular matrix accumulation, although the precise cellular mechanism(s) by which this occurs is not fully understood. The authors have previously shown that the Smad signaling pathway is present and functional in human glomerular mesangial cells and plays a role in activating type I collagen gene expression. It also was determined that TGF-beta1 activates ERK mitogen-activated protein kinase in mesangial cells to enhance Smad activation and… CONTINUE READING