Cytoskeletal protein transformation in HIV-1-infected macrophage giant cells.

  title={Cytoskeletal protein transformation in HIV-1-infected macrophage giant cells.},
  author={Irena Kadiu and Mary Lynn Ricardo-Dukelow and Pawel Ciborowski and Howard E. Gendelman},
  journal={Journal of immunology},
  volume={178 10},
The mechanisms linking HIV-1 replication, macrophage biology, and multinucleated giant cell formation are incompletely understood. With the advent of functional proteomics, the characterization, regulation, and transformation of HIV-1-infected macrophage-secreted proteins can be ascertained. To these ends, we performed proteomic analyses of culture fluids derived from HIV-1 infected monocyte-derived macrophages. Robust reorganization, phosphorylation, and exosomal secretion of the cytoskeletal… CONTINUE READING
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