Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.

@article{Kapanci1995CytoskeletalPM,
  title={Cytoskeletal protein modulation in pulmonary alveolar myofibroblasts during idiopathic pulmonary fibrosis. Possible role of transforming growth factor beta and tumor necrosis factor alpha.},
  author={Yusuf Kapanci and Alexis Desmouli{\`e}re and J C Pache and Mireille Redard and Giulio Gabbiani},
  journal={American journal of respiratory and critical care medicine},
  year={1995},
  volume={152 6 Pt 1},
  pages={2163-9}
}
Pulmonary biopsy specimens from ten cases of idiopathic pulmonary fibrosis (IPF) were examined using routine histological stains, including toluidine blue, and immunohistochemistry by means of specific antibodies against alpha-smooth muscle (alpha-SM) actin, desmin, keratin, TGF beta 1, and TNF alpha. The sections were compared with two cases of normal lung. As shown previously, normal alveolar interstitium did not contain alpha-SM actin positive myofibroblasts nor did the alveolar lining… CONTINUE READING