Cytoskeletal polarity mediates localized induction of the heart progenitor lineage

@inproceedings{Cooley2011CytoskeletalPM,
  title={Cytoskeletal polarity mediates localized induction of the heart progenitor lineage},
  author={James R. Cooley and Stacia Whitaker and Sarah J. Sweeney and Scott E. Fraser and Brad Davidson},
  booktitle={Nature Cell Biology},
  year={2011}
}
Cells must make appropriate fate decisions within a complex and dynamic environment. In vitro studies indicate that the cytoskeleton acts as an integrative platform for this environmental input. External signals regulate cytoskeletal dynamics and the cytoskeleton reciprocally modulates signal transduction. However, in vivo studies linking cytoskeleton/signalling interactions to embryonic cell fate specification remain limited. Here we show that the cytoskeleton modulates heart progenitor cell… CONTINUE READING
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