Cytoskeletal microdifferentiation: a mechanism for organizing morphological plasticity in dendrites.

@article{Kaech2001CytoskeletalMA,
  title={Cytoskeletal microdifferentiation: a mechanism for organizing morphological plasticity in dendrites.},
  author={Stefanie Kaech and Hemant Parmar and Martijn Roelandse and Caroline Bornmann and Andrew Matus},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 13},
  pages={7086-92}
}
Experimental evidence suggests that microfilaments and microtubules play contrasting roles in regulating the balance between motility and stability in neuronal structures. Actin-containing microfilaments are associated with structural plasticity, both during development when their dynamic activity drives the exploratory activity of growth cones and after circuit formation when the actin-rich dendritic spines of excitatory synapses retain a capacity for rapid changes in morphology. By contrast… CONTINUE READING