Cytoskeletal elements link calcium channel activity and the cell cycle in early sea urchin embryos

@inproceedings{Yazaki1995CytoskeletalEL,
  title={Cytoskeletal elements link calcium channel activity and the cell cycle in early sea urchin embryos},
  author={Ikuko Yazaki and Elisabetta Tosti and Brian Dale},
  year={1995}
}
Using the whole-cell clamp technique, we show that L-type calcium channels are activated in early sea urchin blastomeres during M-phase and subsequently inactivated in S-phase. This cyclical channel behaviour occurs in the absence of the nucleus suggesting cytoplasmic regulation independent of the centrosome cycle. Puromycin at 100-400 μM does not prevent inactivation of the current showing that this phase, at least, does not require protein synthesis. Cytochalasin B at 2 μg/ml inhibits the… CONTINUE READING
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Dynamic roles of ion currents in early development.

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