Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system.

@article{Amerongen2001CytoskeletalEO,
  title={Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system.},
  author={Geerten P. van Nieuw Amerongen and Victor W. M. van Hinsbergh},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 3},
  pages={
          300-11
        }
}
Rho-like small GTPases, with their main representatives (Rho, Rac, and Cdc42), have been recognized in the past decade as key regulators of the F-actin cytoskeleton. Rho-like small GTPases are now known to play a major role in vascular processes caused by changes in the actin cytoskeleton, such as smooth muscle cell contraction, endothelial permeability, platelet activation, and leukocyte migration. Data are now accumulating regarding the involvement of Rho GTPases in vascular disorders… CONTINUE READING