Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells

@article{Cabado2003CytoskeletalDI,
  title={Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells},
  author={A. Cabado and F. Leira and M. Vieytes and J. Vieites and L. Botana},
  journal={Archives of Toxicology},
  year={2003},
  volume={78},
  pages={74-85}
}
Okadaic acid (OA) is a tumour promoter that induces apoptosis in several cell models. Following previous findings, the objective of this work was to elucidate the pathways involved in OA-triggered apoptosis in BE(2)-M17 cells by using a combination of pharmacological agents and apoptosis-related assays. OA-induced apoptosis involves disruption of F-actin cytoskeleton, activation of caspase-3, collapse of mitochondrial membrane potential, DNA fragmentation and decreased levels of monomeric Bcl-2… Expand
Okadaic acid induces apoptosis through the PKR, NF-κB and caspase pathway in human osteoblastic osteosarcoma MG63 cells.
  • Ling Chen
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2011
Collapse of mitochondrial membrane potential and caspases activation are early events in okadaic acid-treated Caco-2 cells.
Characteristics of palytoxin-induced cytotoxicity in neuroblastoma cells.
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