Cytoskeletal crosstalk: when three different personalities team up.

Abstract

Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there is growing evidence that the three cytoskeletal subsystems also exhibit strongly coupled functions necessary for polarization, cell migration, and mechano-responsiveness. Here we summarize this evidence from a biophysical point of view, focusing on physical (direct) interactions between the cytoskeletal elements and their influence on cell mechanics and cell migration.

DOI: 10.1016/j.ceb.2014.10.005
050100150201520162017
Citations per Year

149 Citations

Semantic Scholar estimates that this publication has 149 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Huber2015CytoskeletalCW, title={Cytoskeletal crosstalk: when three different personalities team up.}, author={Florian G Huber and Adeline Boire and Magdalena Preciado L{\'o}pez and Gijsje H Koenderink}, journal={Current opinion in cell biology}, year={2015}, volume={32}, pages={39-47} }