Cytoskeletal control of growth and cell fate switching.

  title={Cytoskeletal control of growth and cell fate switching.},
  author={Akiko Mammoto and Donald E. Ingber},
  journal={Current opinion in cell biology},
  volume={21 6},
Living cells must be able to switch between growth and differentiation with high fidelity and precise spatial control to ensure that normal tissue patterns are formed in the embryo and maintained throughout adult life. Most work on cell proliferation focuses on elucidating the signaling pathways responsible for control of cell cycle progression that are triggered by cell binding to soluble growth factors and insoluble extracellular matrix. Here we review recent work, which has revealed that… CONTINUE READING