Cytoskeletal changes induced by allosteric modulators of calcium-sensing receptor in esophageal epithelial cells.

@article{AbdulnourNakhoul2015CytoskeletalCI,
  title={Cytoskeletal changes induced by allosteric modulators of calcium-sensing receptor in esophageal epithelial cells.},
  author={Solange M Abdulnour-Nakhoul and Karen L. Brown and Edd C. Rabon and Youhanna S. Al-Tawil and Mohammed Toriqul Islam and John J. Schmieg and Nazih Labib Nakhoul},
  journal={Physiological reports},
  year={2015},
  volume={3 11}
}
The calcium-sensing receptor (CaSR), a G-protein-coupled receptor, plays a role in glandular and fluid secretion in the gastrointestinal tract, and regulates differentiation and proliferation of epithelial cells. We examined the expression of CaSR in normal and pathological conditions of human esophagus and investigated the effect of a CaSR agonist, cinacalcet (CCT), and antagonist, calhex (CHX), on cell growth and cell-cell junctional proteins in primary cultures of porcine stratified squamous… CONTINUE READING

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