Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma.

@article{Murata2009CytoskeletalCD,
  title={Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma.},
  author={Kazumoto Murata and Hideto Suzuki and Hiroshi Okano and Takashi Oyamada and Yoshikazu Yasuda and Atsushi Sakamoto},
  journal={International journal of oncology},
  year={2009},
  volume={35 5},
  pages={1005-14}
}
Des-gamma-carboxy prothrombin (DCP) is a well-established tumor marker for hepatocellular carcinoma (HCC), but the precise mechanism by which HCC cells produce DCP remains unknown. Our preliminary experiments demonstrated that HepG2 cells with chemical induction of epithelial-to-fibroblastoid conversion (EFC) produced DCP through impairment of vitamin K uptake via cytoskeletal rearrangement. Therefore, in this study we further examined this mechanism in vitro and using human HCC samples… CONTINUE READING