Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP.

@article{Sullivan2007CytoskeletalAO,
  title={Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP.},
  author={Susan Marie Sullivan and Aven Lee and Stella Tracey Bj{\"o}rkman and Stephanie M Miller and Robert Kenneth Sullivan and Philip Poronnik and Paul B Colditz and David V. Pow},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 40},
  pages={
          29414-23
        }
}
Glial fibrillary acidic protein (GFAP) is an enigmatic protein; it currently has no unambiguously defined role. It is expressed in the cytoskeleton of astrocytes in the mammalian brain. We have used co-immunoprecipitation to identify in vivo binding partners for GFAP in the rat and pig brain. We demonstrate interactions between GFAP, the glutamate transporter GLAST, the PDZ-binding protein NHERF1, and ezrin. These interactions are physiologically relevant; we demonstrate in vitro that transport… CONTINUE READING
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