Cytoskeletal alterations in Dictyostelium induced by expression of human cdc42.

@article{Lee2001CytoskeletalAI,
  title={Cytoskeletal alterations in Dictyostelium induced by expression of human cdc42.},
  author={Eunkyung Lee and David A. Knecht},
  journal={European journal of cell biology},
  year={2001},
  volume={80 6},
  pages={399-409}
}
The rho family of small G proteins has been shown to be involved in controlling actin filament dynamics in cells. To evaluate the functional overlap between human and Dictyostelium G proteins, we conditionally expressed constitutively active human cdc42 (V12-cdc42) in Dictyostelium cells. Upon induction, cells adopted a unique morphology: a flattened shape with wrinkles running from the cell edge toward the center. The appearance of these wrinkles is highly dynamic so that the cells cycle… CONTINUE READING

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