Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin.

@article{Jacobson2004CytoskeletalAA,
  title={Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin.},
  author={Jeffrey R. Jacobson and Steven M. Dudek and Konstantin G Birukov and Shui Qing Ye and Dmitry N. Grigoryev and Reda E. Girgis and Joe G. N. Garcia},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={30 5},
  pages={662-70}
}
The statins, a class of HMG-CoA reductase inhibitors, directly affect multiple vascular processes via inhibition of geranylgeranylation, a covalent modification essential for Rho GTPase interaction with cell membrane-bound activators. We explored simvastatin effects on endothelial cell actomyosin contraction, gap formation, and barrier dysfunction produced by the edemagenic agent, thrombin. Human pulmonary artery endothelial cells exposed to prolonged simvastatin treatment (5 microM, 16 h… CONTINUE READING