Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation

@inproceedings{Fritzsche2017CytoskeletalAD,
  title={Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation},
  author={Marco Fritzsche and Ricardo A Fernandes and Veronica T. Chang and Huw Colin-York and Mathias P. Clausen and James H Felce and Silvia Galiani and Christoph Erlenk{\"a}mper and Ana M Santos and John M Heddleston and Isabela Pedroza-Pacheco and Dominic Waithe and Jorge Bernardino de la Serna and B. Christoffer Lagerholm and Tsung-Li Liu and Teng-Leong Chew and Eric Betzig and Simon J Davis and Christian Eggeling},
  booktitle={Science Advances},
  year={2017}
}
T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal remodeling. However, important details on the involvement of actin in the latter transport processes are missing. Using a suite of advanced optical microscopes to analyze resting and activated T cells, we show that, following contact formation with activating surfaces, these cells sequentially rearrange their cortical actin across the… CONTINUE READING
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