Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function

@article{Jaqaman2011CytoskeletalCO,
  title={Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function},
  author={Khuloud Jaqaman and Hirotaka Kuwata and Nicolas Touret and Richard Collins and William S. Trimble and Gaudenz Danuser and Sergio Grinstein},
  journal={Cell},
  year={2011},
  volume={146},
  pages={593-606}
}
The mechanisms that govern receptor coalescence into functional clusters--often a critical step in their stimulation by ligand--are poorly understood. We used single-molecule tracking to investigate the dynamics of CD36, a clustering-responsive receptor that mediates oxidized LDL uptake by macrophages. We found that CD36 motion in the membrane was spatially structured by the cortical cytoskeleton. A subpopulation of receptors diffused within linear confinement regions whose unique geometry… CONTINUE READING
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