Cytoskeletal Control of Antigen-Dependent T Cell Activation

@inproceedings{ColinYork2019CytoskeletalCO,
  title={Cytoskeletal Control of Antigen-Dependent T Cell Activation},
  author={Huw Colin-York and Yousef Javanmardi and Mark Skamrahl and Sudha Kumari and Veronica T. Chang and Satya Khuon and A. M. Robert Taylor and Teng-Leong Chew and Eric Betzig and Emad Moeendarbary and Vincenzo Cerundolo and Christian Eggeling and Marco Fritzsche},
  booktitle={Cell reports},
  year={2019}
}
Cytoskeletal actin dynamics is essential for T cell activation. Here, we show evidence that the binding kinetics of the antigen engaging the T cell receptor influences the nanoscale actin organization and mechanics of the immune synapse. Using an engineered T cell system expressing a specific T cell receptor and stimulated by a range of antigens, we found that the peak force experienced by the T cell receptor during activation was independent of the unbinding kinetics of the stimulating antigen… CONTINUE READING
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