Cytosine arabinoside substitution decreases transcription factor-DNA binding element complex formation.

Abstract

CONTEXT The pyrimidine nucleoside analog, cytosine arabinoside (Ara-C), is an effective therapeutic agent for acute leukemia. The phosphorylated triphosphate, cytosine arabinoside triphosphate, competes with deoxycytosine triphosphate as a substrate for incorporation into DNA. Once incorporated into DNA, it inhibits DNA polymerase and topoisomerase I and… (More)

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Cite this paper

@article{Zhang2004CytosineAS, title={Cytosine arabinoside substitution decreases transcription factor-DNA binding element complex formation.}, author={Ximbo Zhang and Frederick L. Kiechle}, journal={Archives of pathology & laboratory medicine}, year={2004}, volume={128 12}, pages={1364-71} }