Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.

@article{Christensen2007CytoreductiveAA,
  title={Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.},
  author={James G. Christensen and Helen Y. Zou and Maria Elena Arango and Qiuhua Li and Joseph H. Lee and Scott R P McDonnell and Shinji Yamazaki and Gordon R Alton and Barbara Mroczkowski and Gerrit Los},
  journal={Molecular cancer therapeutics},
  year={2007},
  volume={6 12 Pt 1},
  pages={3314-22}
}
A t(2;5) chromosomal translocation resulting in expression of an oncogenic kinase fusion protein known as nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) has been implicated in the pathogenesis of anaplastic large-cell lymphoma (ALCL). PF-2341066 was recently identified as a p.o. bioavailable, small-molecule inhibitor of the catalytic activity of c-Met kinase and the NPM-ALK fusion protein. PF-2341066 also potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean… CONTINUE READING
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