Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug.


We synthesized a cytoprotective magnetic nanoparticle by reacting a maleimide functionalized Feraheme (FH) with a disulfide linked dimer of a polyhis tagged annexin V. Following reductive cleavage of disulfide, the resulting annexin-nanoparticle (diameter = 28.0 ± 2.0 nm by laser light scattering, 7.6 annexin's/nanoparticle) was cytoprotective to cells… (More)
DOI: 10.1039/c4nr06861k


5 Figures and Tables