Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging

Abstract

Background The amyloid precursor protein (APP) is processed via two different metabolic pathways: the amyloidogenic and the non-amyloidogenic pathway, the latter of which leading to generation of the secreted N-terminal APP fragment sAPPa [1]. Previous studies from our group suggest that sAPPa exerts potent neuroprotective effects and inhibits stress-triggered cell death via modulation of gene expression, as well as by antagonizing different types of neurotoxic stress [2]. It was also observed that the biochemical processing of APP is downregulated during aging which in turn reduced the secretion of sAPPa [3]. Based on these observations, we have studied the potential physiological function of sAPPa/APP and APLPs (APP like proteins) on the regulation of ageassociated, stress induced signaling pathways, apoptosis and senescence.

DOI: 10.1186/1750-1326-8-S1-P26

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Cite this paper

@inproceedings{Kundu2013CytoprotectiveFO, title={Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging}, author={Arpita Kundu and Andreas Zymny and Steffi Chang and Nelli R{\"{o}hner and Donat K{\"{o}gel}, booktitle={Molecular Neurodegeneration}, year={2013} }