Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging
Background The amyloid precursor protein (APP) is processed via two different metabolic pathways: the amyloidogenic and the non-amyloidogenic pathway, the latter of which leading to generation of the secreted N-terminal APP fragment sAPPa . Previous studies from our group suggest that sAPPa exerts potent neuroprotective effects and inhibits stress-triggered cell death via modulation of gene expression, as well as by antagonizing different types of neurotoxic stress . It was also observed that the biochemical processing of APP is downregulated during aging which in turn reduced the secretion of sAPPa . Based on these observations, we have studied the potential physiological function of sAPPa/APP and APLPs (APP like proteins) on the regulation of ageassociated, stress induced signaling pathways, apoptosis and senescence.