Cytoprotective effects of acidosis via heat shock protein HSP27 against the anticancer drug doxorubicin

@article{Singh2010CytoprotectiveEO,
  title={Cytoprotective effects of acidosis via heat shock protein HSP27 against the anticancer drug doxorubicin},
  author={Anurag K. Singh and Michael P. Manns and Ursula Seidler},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={68},
  pages={1041-1051}
}
Drug resistance continues to be a stumbling block in achieving better cure rates in several cancers. Doxorubicin is commonly used in treatment of a wide range of cancers. The aim of this study was to look into the mechanisms of how low ambient pH may contribute to down-regulation of apoptotic pathways in a gastric tumour cell line. Low pH culture conditions were found to dramatically prolong cell survival after doxorubicin treatment, an effect that was in part reversed by co-incubation with the… CONTINUE READING