Cytoprotective effect of prostaglandin I2 on ischemia-induced hepatic cell injury.

@article{Sikujara1983CytoprotectiveEO,
  title={Cytoprotective effect of prostaglandin I2 on ischemia-induced hepatic cell injury.},
  author={Osman Sikujara and Morito Monden and Kumao Toyoshima and Junko Okamura and Goro Kosaki},
  journal={Transplantation},
  year={1983},
  volume={36 3},
  pages={238-43}
}
The protective effect of prostaglandin I2 (PGI2) on ischemia-induced liver cell injury was investigated during 60-min, 75-min, and 90-min liver ischemia. Vehicle-treated rats tolerated the 75-min hepatic ischemia poorly. Only 25% of the rats in this group survived more than 7 days. However, the survival rate of PGI2-treated rats (350 ng/kg/min) significantly improved to 67%. Liver cell organelles were well-preserved by the PGI2 treatment. Adenosine triphosphate levels in the liver of the PGI2… CONTINUE READING

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