Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia.

  title={Cytoprotective autophagy maintains leukemia-initiating cells in murine myeloid leukemia.},
  author={Yoshiki Sumitomo and Junji Koya and Kumi Nakazaki and Keisuke Kataoka and Takako Tsuruta-Kishino and Ken Morita and Tomohiko Sato and Mineo Kurokawa},
  volume={128 12},
Despite advances in the treatment of acute myeloid leukemia (AML), relapse and drug resistance frequently occur. Therefore, detailed mechanisms of refractoriness, including leukemia-initiating cell (LIC) biology, should be elucidated to treat AML. The self-degradative property of cytosolic macromolecules is central to autophagy and can contribute to homeostasis and stress response. Recent reports suggest the importance of autophagy in hematopoietic stem cells and various tumors. Thus, this… CONTINUE READING
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