Cytoprotective and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

@article{Lim2012CytoprotectiveAA,
  title={Cytoprotective and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway},
  author={Hyun-dae Lim and Young-Suk Kim and Seok-Ho Ko and I. Yoon and Seong-Guk Cho and Y-H Chun and Byeong-Jun Choi and Eun-Cheol Kim},
  journal={Journal of Pineal Research},
  year={2012},
  volume={53}
}
Abstract:  Melatonin has potent antioxidant, analgesic, and antinociceptive properties. However, the effects of melatonin against oxidative stress‐induced cytotoxicity and inflammatory mediators in human chondrocytes remain poorly understood. This study examined the effects and underlying mechanism of melatonin in hydrogen peroxide (H2O2)‐stimulated human chondrocytes and rabbit osteoarthritis (OA) model. Melatonin markedly inhibited hydrogen peroxide (H2O2)‐stimulated cytotoxicity, iNOS, and… Expand
Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis.
Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway
Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
Plumbagin prevents osteoarthritis in human chondrocytes through Nrf-2 activation.
Oxidative stress in osteoarthritis and antioxidant effect of polysaccharide from angelica sinensis.
Polysaccharide from Angelica sinensis protects chondrocytes from H2O2-induced apoptosis through its antioxidant effects in vitro.
  • C. Zhuang, Nan Xu, +5 authors H. Xie
  • Chemistry, Medicine
  • International journal of biological macromolecules
  • 2016
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