Cytoprotective activity of minocycline includes improvement of mitochondrial coupling: the importance of minocycline concentration and the presence of VDAC.

@article{Karachitos2012CytoprotectiveAO,
  title={Cytoprotective activity of minocycline includes improvement of mitochondrial coupling: the importance of minocycline concentration and the presence of VDAC.},
  author={Andonis Karachitos and Joaqu{\'i}n Jord{\'a}n and Hanna Kmita},
  journal={Journal of bioenergetics and biomembranes},
  year={2012},
  volume={44 3},
  pages={297-307}
}
Available data indicate that minocycline, an antibiotic of the tetracycline family, has cytoprotective properties due to a direct interaction with mitochondria. Yet, the data in the case of isolated mitochondria suggest discrepant or even detrimental effect(s) of the interaction. We have studied the cytoprotective activity displayed by minocycline in the case of the yeast Saccharomyces cerevisiae cells pretreated with H₂O₂. We demonstrated that the activity of minocycline required the presence… CONTINUE READING