Cytoprotection against oxidative stress and the regulation of glutathione synthesis.

@article{Dickinson2003CytoprotectionAO,
  title={Cytoprotection against oxidative stress and the regulation of glutathione synthesis.},
  author={Dale A. Dickinson and Douglas R Moellering and Karen E. Iles and Rakesh P Patel and A L Levonen and Amanda F Wigley and Victor M. Darley-Usmar and Henry Jay Forman},
  journal={Biological chemistry},
  year={2003},
  volume={384 4},
  pages={527-37}
}
Adaptation to oxidative and nitrosative stress occurs in cells first exposed to a nontoxic stress, resulting in the ability to tolerate a toxic challenge of the same or a related oxidant. Adaptation is observed in a wide variety of cells including endothelial cells on exposure to nitric oxide or oxidized lipids, and lung epithelial cells exposed to air-borne pollutants and toxicants. This acquired characteristic has been related to the regulation of a family of stress responding proteins… CONTINUE READING