Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus.

  title={Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus.},
  author={J M Merriam and A B Rubenstein and Michael W Klymkowsky},
  journal={Developmental biology},
  volume={185 1},
Plakoglobin is one of two vertebrate proteins closely related to the Drosophila segment polarity gene product armadillo. Overexpression of plakoglobin induces neural axis duplication in Xenopus and the exogenous plakoglobin is localized to nuclei (Karnovsky, A., and Klymkowsky, M. W., Proc. Natl. Acad. Sci. USA 92, 4255, 1995; Rubenstein, A., et al., Dev. Genet., 1997, in press). We have carried out a series of experiments to test whether the nuclear localization of plakoglobin is required for… CONTINUE READING
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