Cytoplasmic volume modulates spindle size during embryogenesis.

@article{Good2013CytoplasmicVM,
  title={Cytoplasmic volume modulates spindle size during embryogenesis.},
  author={Matthew C Good and Michael D. Vahey and Arunan Skandarajah and Daniel A Fletcher and Rebecca Heald},
  journal={Science},
  year={2013},
  volume={342 6160},
  pages={856-60}
}
Rapid and reductive cell divisions during embryogenesis require that intracellular structures adapt to a wide range of cell sizes. The mitotic spindle presents a central example of this flexibility, scaling with the dimensions of the cell to mediate accurate chromosome segregation. To determine whether spindle size regulation is achieved through a developmental program or is intrinsically specified by cell size or shape, we developed a system to encapsulate cytoplasm from Xenopus eggs and… CONTINUE READING

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