Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

@article{Kamura2004CytoplasmicUL,
  title={Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase},
  author={Takumi Kamura and Taichi Hara and Masaki Matsumoto and Noriko Ishida and Fumihiko Okumura and Shigetsugu Hatakeyama and Minoru Yoshida and Keiko Nakayama and Keiichi I Nakayama},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1229-1235}
}
The cyclin-dependent kinase inhibitor p27Kip1 is degraded at the G0–G1 transition of the cell cycle by the ubiquitin–proteasome pathway. Although the nuclear ubiquitin ligase (E3) SCFSkp2 is implicated in p27Kip1 degradation, proteolysis of p27Kip1 at the G0–G1 transition proceeds normally in Skp2−/− cells. Moreover, p27Kip1 is exported from the nucleus to the cytoplasm at G0–G1 (refs 9–11). These data suggest the existence of a Skp2-independent pathway for the degradation of p27Kip1 at G1… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS