Cytoplasmic tails of beta 1, beta 2, and beta 7 integrins differentially regulate LFA-1 function in K562 cells.

@article{Lub1997CytoplasmicTO,
  title={Cytoplasmic tails of beta 1, beta 2, and beta 7 integrins differentially regulate LFA-1 function in K562 cells.},
  author={Marijke Lub and Sandra J van Vliet and S P Oomen and Robrecht Pieters and Micah Robinson and C G Figdor and Yvette van Kooyk},
  journal={Molecular biology of the cell},
  year={1997},
  volume={8 4},
  pages={
          719-28
        }
}
The beta 2 integrin lymphocyte function-associated antigen 1 (LFA-1) mediates activation-dependent adhesion of lymphocytes. To investigate whether lymphocyte-specific elements are essential for LFA-1 function, we expressed LFA-1 in the erythroleukemic cell line K562, which expresses only the integrin very late antigen 5. We observed that LFA-1-expressing K562 cannot bind to intercellular adhesion molecule 1-coated surfaces when stimulated by phorbol 12-myristate 13-acetate (PMA), whereas the… CONTINUE READING
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