Cytoplasmic ribonucleic acid synthesis in the prereplicative phase of isoproterenol-induced cell proliferation.

@article{Sasaki1970CytoplasmicRA,
  title={Cytoplasmic ribonucleic acid synthesis in the prereplicative phase of isoproterenol-induced cell proliferation.},
  author={T. Sasaki and Renato Baserga},
  journal={Experimental and molecular pathology},
  year={1970},
  volume={13 1},
  pages={
          25-35
        }
}
  • T. Sasaki, R. Baserga
  • Published 1 August 1970
  • Biology, Medicine
  • Experimental and molecular pathology
Abstract The appearance of radioactivity in cytoplasmic RNA was investigated in the salivary glands of mice injected with uridine-3H at various times after a single intraperitoneal administration of isoproterenol (IPR). The results showed that: (1) the minimum time required for the appearance of radioactivity in cytoplasmic ribosomal RNA was the same in unstimulated and stimulated glands; (2) the incorporation of uridine-3H into cytoplasmic rRNA was much higher in stimulated than in control… 
Turnover of ribosomal RNA in the submandibular gland of normal and isoproterenol-treated rats.
  • T. Barka
  • Biology, Medicine
    Experimental cell research
  • 1972
TLDR
An attempt was made to measure the half-life of ribosomal RNA in the submandibular gland during an accelerated hypertrophic and hyperplastic growth of the gland produced by the repeated administration of isoproterenol.
Age-dependent regulation of isoproterenol-stimulated DNA synthesis in rat salivary gland in vivo.
TLDR
It is proposed that the initial age dependent modification relates to either the stimulated appearance of crucial RNA species between 5 and 10 hr following isoproterenol treatment, or an early biochemical action of the drug, distinct from its membrane receptor binding which enhances secretion of α-amylase.
Effect of irradiation on mouse salivary glands during the prereplicative phase of isoproterenol-stimulated DNA synthesis.
TLDR
Results indicate that the highly radiosensitive phase, 1 hr after the second injection of isoproterenol, was not related only to the ability of IPR to produce secretion in the salivary glands but was related rather to the early biochemical events leading to DNA synthesis in Salivary gland cells.
Studies on chromatin-associated protein phosphokinase of submandibular gland from isoproterenol-treated rats.
TLDR
The results suggest that the isoproterenol-induced increase in chromatin-bound protein phosphokinase which precedes the increase in RNA synthesis is related to the eventual onset of DNA synthesis in rat submandibular gland stimulated by isoprotserenol.
Studies on phosphoproteins of submandibular gland nuclei isolated from isoproterenol-treated rats.
TLDR
The results suggest that the phosphorylation of the non-histone phosphoproteins plays an important role in the events controlling the synthesis of RNA which precedes the replication of DNA and cell and the regulation of the metabolism of nuclear phosphoprotein may be controlled through a function of the cytoplasmic membrane.
Collagen turnover in isoproterenol-induced DNA synthesis and its modification by x-ray irradiation.
TLDR
Both degradation and synthesis of collagen seemed to be correlated to the events leading to isoproterenol-stimulated DNA synthesis of epithelial cells in vivo.
Ribosomal RNA synthesis in WI-38 cells stimulated to proliferate.
Abstract When confluent monolayers of WI-38 human diploid fibroblasts are stimulated to proliferate by a change of medium containing 10% fresh serum, synthesis of DNA begins to increase between 12
The effect of isoproterenol upon the chemical composition of plasma membranes in the mouse parotid gland.
TLDR
It is concluded that the separation of sialic acid from the plasma membrane is one of the early steps in the sequence of events leading to DNA synthesis and cell division in the isoproterenol-stimulated parotid gland of mice.
Inhibition by x-irradiation and antimetabolites of DNA synthesis without affecting cAMP elevation in isoproterenol-stimulated mouse parotid gland.
TLDR
It is concluded that the critical step in the initiation of stimulated DNA synthesis may be located at a period later than the initial cAMP elevation, and X-irradiation or certain metabolic inhibitors, administered prior to isoproterenol, completely inhibited the stimulatedDNA synthesis.
The effect of isoproterenol and cycloheximide on protein synthesis and growth in mouse parotid.
TLDR
Isoproterenol appears to alter the organization and function of the acinar cells making the effects of cycloheximide more intense and prolonged than upon nonstimulated glands, therefore, the results cannot be extrapolated to glands that have been stimulated by isoprotereol.
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The results indicate that isoproterenol causes an early stimulation of protein synthesis in mouse salivary gland and that this stimulation is relevant to the subsequent onset of DNA synthesis.
Stimulation of DNA synthesis by isoproterenol in the salivary gland.
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  • Biology, Medicine
    Experimental cell research
  • 1965
TLDR
The results suggested that the cell proliferation in the salivary gland induced by isoproterenol may be regulated by a number of factors but the triggering mechanism probably acts on a genetic level.
Stimulation of DNA synthesis by isoproterenol and its inhibition by actinomycin D.
TLDR
The stimulation of DNA synthesis by isoproterenol is sensitive to small amounts of actinomycin D, insufficient to produce rapid changes in protein synthesis or ATP content of salivary glands.
Inhibition of stimulation of DNA synthesis by isoproterenol in submandibular glands of mice
Harks (1) has shown that a single injection of isoproterenol (IPR) in rate produces, 24 hours later, a 10-fold increase in DNA synthesis in the salivary glands . The increase in DNA synthesis is
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  • Biology, Medicine
    Experimental cell research
  • 1966
TLDR
Isoproterenol stimulated the incorporation of 3H-uridine and3H-orotic acid into total and nuclear RNA fractions of rat and it was sensitive to actinomycin D.
Changes in thymidine kinase and alpha-amylase activity during isoproterenol-stimulated DNA synthesis in mouse salivary gland.
TLDR
The activity of thymidine kinase and α-amylase was determined in the time interval between injection of isoproterenol and the peak of DNA synthesis, both under optimal conditions of stimulation and under conditions that modify the gland9s proliferative response to isoprotserenol.
Localization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells.
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Three heterogeneous RNA species in HeLa cells have been characterized with respect to kinetics of labeling, turnover and location, showing that the nucleoplasmic, cytoplasmic and polyribosome-associated messenger fractions are relatively unaffected by doses of actinomycin which completely inhibit ribosomal RNA synthesis.
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A centrifugation method for the fractionation of the postmitochondrial fraction from rat-liver homogenates, in which no detergent is used, may be used as a tool to discriminate between two classes of ribosomes.
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  • Medicine, Biology
    The Journal of biological chemistry
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TLDR
Polysomes of rat liver appear to be either attached to the membrane of the endoplasmic reticulum or free in the cytoplasm, and over 80% of the protein synthesized by attached Ribosomes was found to be serum proteins, and the free ribosomes made 7 to 20 times more ferritin than did attached ribosome.
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TLDR
After a second injection of IPR, DNA synthesis is depressed until high levels of glycogen are restored, since any induced decrease in peak glycogen concentration results in a decreased incorporation of 3HTdR into DNA.
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