Cytoplasmic polyadenylation in development and beyond.

  title={Cytoplasmic polyadenylation in development and beyond.},
  author={Joel D. Richter},
  journal={Microbiology and molecular biology reviews : MMBR},
  volume={63 2},
  • Joel D. Richter
  • Published 1999 in Microbiology and molecular biology reviews : MMBR
Maternal mRNA translation is regulated in large part by cytoplasmic polyadenylation. This process, which occurs in both vertebrates and invertebrates, is essential for meiosis and body patterning. In spite of the evolutionary conservation of cytoplasmic polyadenylation, many of the cis elements and trans-acting factors appear to have some species specificity. With the recent isolation and cloning of factors involved in both poly(A) elongation and deadenylation, the underlying biochemistry of… CONTINUE READING
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The CPE mediates masking and unmasking of cyclinB1 mRNA

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