Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest.

@article{Read2002CytoplasmicPP,
  title={Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest.},
  author={Rebecca L Read and Rui Gonçalo Martinho and S. W. Wang and Antony M Carr and Chris J. Norbury},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 19},
  pages={12079-84}
}
The S-M checkpoint delays mitosis until DNA replication is complete; cells defective in this checkpoint lose viability when DNA replication is inhibited. This inviability can be suppressed in fission yeast by overexpression of Cid1 or the related protein Cid13. Fission yeast contain six cid1/cid13-like genes, whereas budding yeast has just two, TRF4 and TRF5. Trf4 and Trf5 were recently reported to comprise an essential DNA polymerase activity required for the establishment of sister chromatid… CONTINUE READING