Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer

@article{Wendum2005CytoplasmicPA,
  title={Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer},
  author={Dominique Wendum and Eva Comperat and Pierre-Yves Bo{\"e}lle and Rolland Parc and Jo{\"e}lle Masliah and Germain Trugnan and Jean-François Fl{\'e}jou},
  journal={Modern Pathology},
  year={2005},
  volume={18},
  pages={212-220}
}
In colorectal cancer, cyclooxygenase-2 (COX-2) overexpression in stromal cells induces angiogenesis through EP2 prostaglandin E2 receptor signaling. Cytoplasmic phospholipase A2 (PLA2) alpha preferentially hydrolyses arachidonic acid, which is the limiting substrate for prostaglandin production, from membrane phospholipids. We therefore investigated a possible relationship between cytoplasmic PLA2 and COX-2 overexpression in stromal cells, angiogenesis and microsatellite instability in 48 human… CONTINUE READING

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