Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.

  title={Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.},
  author={Anna Maria Teti and Harry C. Blair and Steven L Teitelbaum and Arnold J. Kahn and Claudia Koziol and J D Konsek and A. Zambonin-Zallone and Paul H Schlesinger},
  journal={The Journal of clinical investigation},
  volume={83 1},
Osteoclasts resorb bone by first attaching to the bone surface and then secreting protons into an isolated extracellular compartment formed at the cell-bone attachment site. This secretion of protons (local acidification) is required to solubilize bone hydroxyapatite crystals and for activity of bone collagen-degrading acid proteases. However, the large quantity of protons required, 2 mol/mol of calcium, would result in an equal accumulation of cytosolic base equivalents. This alkaline load… CONTINUE READING
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