Cytoplasmic pH change induced by leukotriene B4 in human neutrophils.

  title={Cytoplasmic pH change induced by leukotriene B4 in human neutrophils.},
  author={Hideki Sumimoto and Manami Satoh and Koichiro Takeshige and Edward J. Cragoe and Shigeki Minakami},
  journal={Biochimica et biophysica acta},
  volume={970 1},
Leukotriene B4 induced a biphasic change in the cytoplasmic pH of human neutrophils: an initial rapid acidification followed by an alkalinization. The acidification was slightly reduced by the removal of extracellular Ca2+, but the subsequent alkalinization was not. The leukotriene B4-induced alkalinization was dependent on extracellular Na+ and pH, and was inhibited by amiloride and its more potent analogue, 5-(N,N-hexamethylene)amiloride. These characteristics indicate that the cytoplasmic… CONTINUE READING