Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer.

  title={Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer.},
  author={Gizeh P{\'e}rez-Tenorio and Fredrik Berglund and Anna Esguerra Merca and B O Nordenskj{\"o}ld and Lars Erik Rutqvist and Lambert Skoog and Olle St{\aa}l},
  journal={International journal of oncology},
  volume={28 5},
P21WAF1/Cip1 (p21) translocates to the cytoplasm inducing cell cycle progression and survival upon Akt/PKB activation. We studied whether heregulin beta1 (HRGbeta1), that activates the PI3K/Akt and MAPK pathways, also misallocates p21. We also explored whether HRGbeta1 interferes with the effects of tamoxifen. The clinical material studied helped us to clarify whether p21 was associated with phosphorylated Akt, recurrence-free survival and response to tamoxifen. MCF-7 cells treated with… CONTINUE READING


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