Cytoplasmic organization of POXvirus DNA replication.

  title={Cytoplasmic organization of POXvirus DNA replication.},
  author={Birgit Schramm and Jacomine Krijnse Locker},
  volume={6 10},
Poxviruses, a family of large DNA viruses, are unique among DNA viruses, because they carry out DNA replication in the cytoplasm rather than the nucleus. This process does not occur randomly, but instead, these viruses create cytoplasmic 'mini-nuclei', distinct sites that are surrounded by membranes derived from the rough endoplasmic reticulum (ER) that support viral replication. This review summarizes how distinct steps preceding cytoplasmic DNA replication, as well as replication itself… CONTINUE READING

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