Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.

@article{Takatori2008CytoplasmicLA,
  title={Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.},
  author={Sho Takatori and Genta Ito and Takeshi Iwatsubo},
  journal={Neuroscience letters},
  year={2008},
  volume={430 1},
  pages={13-7}
}
Mutations in PTEN-induced putative kinase 1 (PINK1) gene have been linked to an autosomal recessive form of familial Parkinson's disease. PINK1 encodes a predicted mitochondrial protein kinase. Although the mitochondrial localization of PINK1 has been suggested, the exact subcellular compartment in which PINK1 exerts its cytoprotective function is elusive. Thus, we studied the subcellular distribution and metabolism of PINK1 in cultured cells. Immunocytochemical analysis showed that PINK1… CONTINUE READING

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