Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism.

@article{Russell2007CytoplasmicLD,
  title={Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism.},
  author={Tanya D. Russell and Carol A. Palmer and David J Orlicky and Andreas Fischer and Michael C Rudolph and Margaret C. Neville and James L McManaman},
  journal={Journal of lipid research},
  year={2007},
  volume={48 7},
  pages={1463-75}
}
PAT proteins (perilipin, adipophilin, and TIP47) are hypothesized to be critical regulators of lipid accumulation in eukaryotic cells. We investigated the developmental relationships between the expression of these proteins and cytoplasmic lipid droplet (CLD) accumulation in differentiating secretory epithelial cells in mouse mammary glands. Adipophilin (ADPH) specifically localized to CLD in differentiating and lactating mammary glands and was found exclusively in the secreted lipid droplet… CONTINUE READING