Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules.

@article{Binker2007CytoplasmicLP,
  title={Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules.},
  author={Marcelo Gustavo Binker and Dorothy Yanling Zhao and Sophie J. Y. Pang and Rene E Harrison},
  journal={Journal of immunology},
  year={2007},
  volume={179 6},
  pages={3780-91}
}
Activation of macrophages causes increased cell spreading, increased secretion of cytokines and matrix metalloproteinases, and enhanced phagocytosis. The intracellular mechanisms driving the up-regulation of these activities have not been completely clarified. We observe that classical activation of murine resident peritoneal or RAW 264.7 macrophages with a combination of IFN-gamma and LPS induces an increase in stabilized cytoplasmic microtubules (MTs), measured with an anti-acetylated alpha… CONTINUE READING
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