Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus.

@article{Dupin2011CytoplasmicIF,
  title={Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus.},
  author={Isabelle Dupin and Yasuhisa Sakamoto and Sandrine Etienne-Manneville},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 6},
  pages={865-72}
}
The localization of the nucleus is precisely regulated, and defects in nuclear positioning are observed in diseases such as lissencephaly, cerebellar ataxia and dysplasia. We show here that cytoplasmic intermediate filaments are essential players in actin-dependent positioning of the nucleus. The actin retrograde flow is relayed by a flow of intermediate filaments that accumulate asymmetrically around the nuclear envelope. Perturbations of the intermediate filament network alter positioning of… CONTINUE READING